On 11 June 2022, it was announced that Tchouaméni would be transferred from Bordeaux to La Liga side Real Madrid on 1 July 2022, signing a six-year contract with the club. The transfer fee was reported to be €80 million, which could rise to €100 million due to additional fees.
He made his official debut for the club on 10 August, coming on as a late substitute in a 2:0 win over Eintracht Frankfurt in the UEFA Super Cup to win his first career club trophy. On 30 September 2023, Tchouaméni scored his first goal for Los Blancos, a header in a 3:0 league away win over Girona.
On 1 September 2021, he made his international debut in a 2022 FIFA World Cup qualifying game against Bosnia and Herzegovina, replacing Thomas Lemar in the 46th minute. On 25 March 2022, Tchouaméni scored his first goal for the national team in a friendly against the Ivory Coast.
